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Phenylbutazone (also known as Bute)
PHENYLBUTAZONE RESCHEDULED AND DECLARED A PROHIBITED SUBSTANCE
Phenylbutazone has been rescheduled as a Schedule 7 substance (previously a Schedule 6 medicine) and consequently declared a prohibited substance, effective as from 8 May 2014, the date of publication of the Amendment to the Schedules (including Schedule 7) published in terms of section 22A of Act 101 of 1965 in Government Gazette Number 37622 under Notice Number R352.
The amendments, including the rescheduling came into operation on the date of publication of the Government Gazette. In short it means that NO PERSON may acquire, use, possess, manufacture or supply a Schedule 7 substance.
Altrenogest is used to suppress oestrus in mares, and its use for this specific purpose is allowed under FEI rules. Its use in a male horse (gelding or stallion) is not permissible.
Earlier this year, Australian racehorses tested positive for the anabolic agents Trendione and Trenbolone following administration of Altrenogest. The investigation revealed that traces of these two substances could be found in Altrenogest products as a result of the manufacturing process in a specific factory. Following the investigation some horse sport regulatory bodies have issued a warning regarding the use of Altrenogest.
The FEI has conferred with the Director of the FEI Central Laboratory and can confirm that, with the currently available information, it is permissible to continue to use Altrenogest product Regu-Mate Solution 2.2 mg/mL for mares as per the manufacturer’s instructions. The FEI Veterinary Department recommends that anyone using or planning to use the product on a mare should discuss this with their veterinarian.
(a) The REFERENCE specimen is not at all handled at the NHA Lab.
(b) Following the initial centrifugation SeroPreg Laboratory reseals in the one bottle the REFERENCE plasma supernatant sample and the also the cell pellet sample.
(c) Only when there is a positive finding which is contested the following mechanism comes into play for the REFERENCE SAMPLE:
The bottle is opened, the cell tube (for DNA confirmation) is placed in labelled bottle of its own and the bottle is sealed. The sealed bottle is placed in a security bag. This can be sent for DNA typing.
When the bottle is opened, the other tube, a plasma tube (for prohibited substance confirmation) is placed in label bottle of its own. Now for the first time ice pack material is added and the bottle is then sealed. The sealed bottle is placed in a security bag.
This can be sent to an accredited Laboratory for prohibited substance testing.
FEI Supplement Warning
2023 FEI Equine Prohibited Substances List (EPSL)
2023 FEI EPSL - Banned Substances
2023 FEI EPSL - Controlled Medication
Saalperdgenootskap van Suid-Afrika
Warning Regarding Use of Altrenogest
FEI Warning regarding synephrine
Prohibited Substances Letter March 2024
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